About
David A. Sinclair, AO, PhD is a tenured Professor of Genetics at Harvard Medical School and founding director of the Paul F. Glenn Center for the Biology of Aging Research there. His lab helped define the modern longevity conversation through sirtuin and NAD+ biology, the Information Theory of Aging, and partial reprogramming work with Yamanaka factors. He is the author of Lifespan, an inventor on 50+ patents, a co-founder of companies including Sirtris, Life Biosciences, Metro Biotech, and Tally Health, and a Scientific Advisory Board member at InsideTracker.
What to Know
Signature approach
Sinclair’s lab studies aging as a molecular and epigenetic process: sirtuins, NAD+ biology, caloric-restriction signaling, and partial reprogramming with Yamanaka factors. The practical thesis is that some age-related decline may be measurable, modifiable, and eventually reversible at the cellular level. That scientific arc connects his academic work to biological-age testing, healthspan analytics, and longevity biotech.
What sets them apart
- Frame-defining research arc. His lab’s sirtuin, NAD+, and Information Theory of Aging work helped shape how the field talks about why we age.
- Rare public reach for an academic scientist. Lifespan brought longevity biology to a mainstream audience while his Harvard lab and patents kept the work tied to translational programs.
- Company-building footprint. Sirtris, Life Biosciences, Metro Biotech, Tally Health, and InsideTracker advisory work put him across several parts of the longevity ecosystem.
Affiliations
Co-Founder
Scientific Advisor
Thought Leadership
Books
- Lifespan: Why We Age – and Why We Don't Have To · Atria Books / Simon & Schuster, 2019
Publications
- Loss of epigenetic information as a cause of mammalian aging · Cell, 2023
- Reprogramming to recover youthful epigenetic information and restore vision · Nature, 2020
- The economic value of targeting aging · Nature Aging, 2021
- SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging · Cell, 2008
Media Appearances
- 60 Minutes feature on aging research · CBS 60 Minutes
- Through the Wormhole with Morgan Freeman · Science Channel
- AI for Good Summit 2025 · United Nations ITU · 2025
Notable Collaborators
- Leonard (Lenny) Guarente, PhD · Sirtuins, NAD+, biology of aging — postdoctoral advisor at MIT and fellow InsideTracker SAB member
Other specialists at Tally Health
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