Founder-led N-of-1 precision medicine for hormones, metabolism, and healthy aging
Founder-led concierge precision medicine across three US centers with longitudinal biomarkers and healthy-aging care
Comite Center for Precision Medicine & Healthy Longevity is a concierge precision-medicine practice founded in 2005 by Florence Comite, MD, a Yale-trained endocrinologist with a long academic background in hormones, metabolism, and women's health. The practice now lists three centers: New York City, the Bay Area, and Miami Beach. Its core model is N-of-1™ care, meaning each patient is followed against their own baselines and trends rather than treated from a generic protocol. Biomarkers, wearables, lifestyle work, and targeted medical interventions are combined into a longitudinal healthy-aging program.
Care follows an N-of-1™ framework: each patient is treated as their own clinical study. The team looks for patterns across repeat biomarker panels, wearable data, health history, and clinical response, then adjusts the plan over time. The goal is to catch metabolic, hormonal, cognitive, and cardiovascular drift early enough to intervene before disease becomes the organizing event.
Genetics
Metabolic markers
Epigenetics
Hormones (sex hormones, thyroid, adrenal)
Lipid profile
Inflammatory markers
Organ-system function
Repeat panels at clinical intervals
Trend analysis vs. single-point screening
Wearables integration (CGM, sleep, HRV, activity)
Andropause and male hormone tuning
Perimenopause and menopause management
Endocrine work across the lifespan
Diabetes risk and reversal
Cardiovascular risk profiling
Lipid management
Early dementia and Alzheimer's risk identification
Cognitive-performance baselines
Early detection workups
Risk-factor monitoring
Nutrition and exercise programming
Sleep and stress protocols
Targeted supplementation
Evidence-based pharmacology where indicated
Pricing is handled through inquiry rather than a public tier menu. Treat Comite as a high-touch concierge longitudinal program, not a one-time executive physical: the cost conversation should cover annual access, repeat biomarker panels, clinician follow-up, and any medications, supplements, imaging, or specialty work billed separately. Medicare opted-out status is listed for Dr. Comite on IDNY, so plan around self-pay concierge economics. Ask which diagnostic line items can be submitted through HSA/FSA or insurance paperwork.
Insurance: Self Pay · HSA/FSA: Partial
Treat membership or concierge-program fees as unlikely to qualify. Select lab, imaging, or diagnostic line items may be eligible depending on plan rules, so confirm with Comite and your plan administrator.
Comite is built around an N-of-1 model: patients are tracked against their own biomarker trends over time, then care is adjusted through lifestyle, supplements, medical interventions, and follow-up.
No. The practice is positioned as a longitudinal concierge program with repeat testing and ongoing clinical interpretation, not a single annual screening day.
Expect concierge self-pay economics. During intake, ask for the annual program fee, what repeat testing includes, and which medications, supplements, imaging, or specialist work may be billed separately.
Comite lists centers in New York City, the Bay Area, and Miami Beach. NYC is the original center; the Bay Area listing is in Mountain View under the broader Palo Alto framing.
Florida access point for Florence Comite, MD's N-of-1 precision-medicine program, established in 2022
Bay Area access point for Florence Comite, MD's longitudinal precision-medicine program in Mountain View
Original Manhattan home of Dr. Florence Comite's N-of-1 precision-medicine practice on Central Park South
Yale-trained endocrinologist applying N-of-1 precision medicine to hormones, metabolism, and healthy aging
Comite Center for Precision Medicine & Healthy Longevity
Bliss, THE WELL, Remede, Starwood, and Arch Amenities Group operator shaping the concierge experience
Comite Center for Precision Medicine & Healthy Longevity
25+ years across NY-Presbyterian and Mount Sinai, now shaping partnerships and client experience across three centers
Comite Center for Precision Medicine & Healthy Longevity
Hospitality, CMA, and MBA background behind therapeutic logistics, supply chain, and client support
Comite Center for Precision Medicine & Healthy Longevity
10+ years in integrative medicine with a patient-education-first precision-care style
Comite Center for Precision Medicine & Healthy Longevity
Internal-medicine PA-C focused on biomarker-driven longevity care, metabolic health, hormones, and weight management
Comite Center for Precision Medicine & Healthy Longevity
Psychiatric PA background with 20+ years in healthcare and six years in ketamine infusion therapy
Comite Center for Precision Medicine & Healthy Longevity
Primary-care PA-C turned precision-medicine clinician focused on prevention, nutrition, and chronic-disease risk
Comite Center for Precision Medicine & Healthy Longevity
Men's Health, Rodale, Galvanized Media, and NYT bestselling author experience applied to healthy-aging education
Comite Center for Precision Medicine & Healthy Longevity
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