Manuel Puntschuh, MD, eMBA, FMH
CEO | Lead Longevity Medicine · Origin Health
FMH internist leading Origin Health longevity medicine with epigenetic testing, IHHT, NAD+, and preventive-health platforms
About
Manuel Puntschuh, MD is CEO and Lead Longevity Medicine at Origin Health in Basel. He trained in medicine at the University of Kiel, holds an executive MBA from Quantic School of Business and Technology, and is an FMH-certified specialist in general internal medicine. Before Origin Health, he worked in emergency and general practice settings, led Medgate Mini Clinics, founded a digital-health consulting practice, became CMO at preventive-health platform Aeon, and joined the AVEA Life Scientific Advisory Board. At Origin, he leads the longevity track around biological-age testing, epigenetics, mitochondrial function, metabolic health, NAD+, IHHT, and personalized supplementation.
What to Know
Signature approach
Puntschuh's work is built around measuring aging biology before symptoms become the main signal. His track can include epigenetic clocks, advanced biomarkers, mitochondrial markers, metabolic health evaluation, microbiome analysis, genetic insights, and full-body imaging through partner platforms. Treatment then maps to the findings: IHHT for mitochondrial conditioning, NAD+ or glutathione infusions, targeted supplementation, metabolic protocols, and repeated measurement through the membership cadence.
What sets them apart
- Longevity plus operations background. He has led Medgate Mini Clinics, advises AVEA Life, and serves as CMO at Aeon, giving him direct exposure to preventive imaging, supplements, and scaled healthcare delivery.
- Biological-age focus. His Origin Health track is explicitly built around hallmarks-of-aging biology, epigenetics, mitochondrial health, metabolic pathways, and measurable prevention.
- Pragmatic longevity voice. His public interviews emphasize sleep, exercise, nutrition, stress, and targeted interventions rather than a single-product view of longevity.
Before You Book
- Care focus. Start with Puntschuh when the priority is biological-age testing, epigenetics, mitochondrial health, NAD+, IHHT, metabolic optimization, or a structured longevity protocol.
- Access varies by tier. Personal 24/7 access to him is tied to the Elite Care membership, so confirm response expectations before choosing a plan.
- Parallel roles. He also works with Aeon and AVEA Life, which may be a plus for preventive-health context but is worth understanding when discussing availability.
- Functional symptoms. For chronic fatigue, gut, hormone, autoimmune, and root-cause functional-medicine questions, Joris Budweg leads that track.
Expertise
Focus areas
Protocols & technologies
Conditions treated
4Chronic fatigue
Chronic fatigue syndrome
Insulin resistance
Insulin resistance / prediabetes
Chronic inflammation
Inflammaging / systemic inflammation
Autoimmune conditions
Autoimmune disorders
Credentials
Education
MD
Christian-Albrechts-Universitat zu Kiel (University of Kiel)
eMBA
Quantic School of Business and Technology
Board certifications
Specialist in General Internal Medicine
FMH (Swiss Medical Association)
Swiss national board certification in general internal medicine - the standard specialist qualification for internists in Switzerland.
Years in practice
15
Affiliations
Thought Leadership
Media Appearances
- Five opinions on an open end - The hype around longevity · Horizons Magazine (Swiss National Science Foundation) · 2025-12-04
- The science of longevity with Dr. Manuel Puntschuh - LongevityUnlocked series · AVEA Life Insights
Other specialists at Origin Health
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